منابع مشابه
Bioanalytical chemistry: Protein oligomers frozen in time.
When Fenn and co-workers recorded early electrospray ionization (ESI) mass spectra of biopolymers, they observed what are now characteristic charge-state distributions as well as the formation of non-covalent complexes that persisted into the gas phase1. Writing on page 326 of this issue2, Bernstein et al. describe the remarkable diff erences in the distributions of oligomers formed by diff ere...
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In this issue of Structure, Chen et al. (2015) report the use of a mixing-spraying method of time-resolved cryogenic electron microscopy, which allowed the progression of ribosomal subunit association to be visualized on the millisecond timescale.
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The ribosome is imprinted with a detailed molecular chronology of the origins and early evolution of proteins. Here we show that when arranged by evolutionary phase of ribosomal evolution, ribosomal protein (rProtein) segments reveal an atomic level history of protein folding. The data support a model in which aboriginal oligomers evolved into globular proteins in a hierarchical step-wise proce...
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SUMMER 2008 BETA 31 Trauma : “I can’t remember anything after the first few words she said: ‘I’m sorry to tell you that your test results came back positive.’ After that, it was all just a blur of sounds and images—the traffic outside, my heart beating, the look on her face. Everything was moving in slow motion. I just kept hearing those five words echoing in my head: ‘Your test came back posit...
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Conventionally, most in vitro fertilization (IVF) embryos are transferred in fresh treatment cycles with freezing reserved for spare ones. Improvement in cryopreservation facilities over time has encouraged the greater use of this technology with the success rate of frozen replacement cycles approaching that associated with fresh embryo transfer. Data from observational studies suggest that obs...
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ژورنال
عنوان ژورنال: Anesthesia & Analgesia
سال: 2018
ISSN: 0003-2999
DOI: 10.1213/ane.0000000000003423